The goal of the Institute is to explore the interfaces of fundamental biological science, clinical science, and clinical care with a special emphasis on targeted cancer therapy. The current focus centers on signaling by protein kinases. These enzymes (protein kinases) play a key regulatory role in nearly every aspect of cell biology. Owing to the myriad actions of protein kinases, it is imperative that they be stringently regulated because aberrant activity of these enzymes can lead to a variety of diseases including, inter alia, cancer, diabetes and autoimmune, cardiovascular, degenerative, inflammatory, and nervous disorders. Because mutations and dysregulation of protein kinases play causal roles in human disease, these enzymes represent attractive drug targets. Our current research focuses on the vascular endothelial growth factor protein-tyrosine kinases. Inhibition of these enzymes represents a promising therapy for tumor progression and for age-related macular degeneration of the eye, diseases that are associated with abnormal, or pathological, blood vessel growth (angiogenesis).  

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