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The goal of the Institute is to explore the interfaces of fundamental biological science, clinical science, and clinical care with a special emphasis on targeted cancer therapy. The current focus centers on signaling by protein kinases. These enzymes (protein kinases) play a key regulatory role in nearly every aspect of cell biology. Owing to the myriad actions of protein kinases, it is imperative that they be stringently regulated because aberrant activity of these enzymes can lead to a variety of diseases including, inter alia, cancer, diabetes and autoimmune, cardiovascular, degenerative, inflammatory, and nervous disorders. Because mutations and dysregulation of protein kinases play causal roles in human disease, these enzymes represent attractive drug targets. Our current research focuses on the Raf protein kinases and on the regulation of tyrosine hydroxylase activity by protein phosphorylation. To contact us by e-mail: Webmaster@brimr.org. Thank you for visiting this site. |
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Research is the hardest and finest game. – Ernest Henry Starling. |
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Medicine evolved from a therapeutic art into a therapeutic science,
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| based on a reductionist approach derived from biochemistry and later | |
| It is nice to know that the computer understands the problem, | |
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but I would like to understand it too. – Eugene
P. Wigner
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When you get to a fork in the road, take it. – Yogi
(Lawrence Peter) Berra
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| Robert Roskoski Jr. MD, PhD. | Institute Research Goals | News Items | |
| Scientific Director | Humor | ||
| Background, Robert Roskoski, Sr. circa 1940 | North Carolina Photos | ||
| e-mail: rrj@brimr.org
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NIH Funding Rank of US Medical Schools from 2006-2009 |
Protein Kinase and Phosphatase Research Sites |
Common Sense Health Tips |
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The Blue Ridge Institute for Medical Research is a Federal tax exempt 501(c)(3) non-profit organization incorporated in the State of North Carolina on 24 March 2006 (EIN 20-4665742; DLN 17053144012016). |
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Updated 12 June 2010 |
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